Tirzepatide
| Lebitso le akaretsang: | Tirzepatide |
| Nomoro ea Cas: | 2023788-19-2 |
| Foromo ea molek'hule: | C225H348N48O68 |
| Boima ba molek'hule: | 4813.45 g/mol |
| Tatelano: | H-Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{diacid-gamma-Glu -(AEEA)2-Lys}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Ponahalo: | Phofo e tšoeu |
| Kopo: | Tirzepatide ke sethethefatsi se ithutoang bakeng sa tšebeliso ea sona e ka bang teng ho alafa lefu la tsoekere la mofuta oa 2. Ke ea sehlopha sa lithethefatsi tse bitsoang diglucose-dependent insulinotropic peptide (GIP) le glucagon-like peptide-1 (GLP-1) receptor agonists. Tezepatide e sebetsa ka ho susumetsa li-receptor tsa GIP le GLP-1 'meleng. Li-receptor tsena li bapala karolo ea bohlokoa ho laola maemo a tsoekere ea mali le metabolism. Ka ho kenya tšebetsong li-receptor tsena, tezepatide e eketsa tlhahiso ea insulin mme e fokotsa secretion ea glucagon, hormone e phahamisang maemo a tsoekere maling. E boetse e liehisa ho tsoa ka mpeng le ho thusa ho laola maemo a tsoekere ea mali. Liteko tsa kliniki li bonts'itse hore tilsiparatide e khona ho laola tsoekere ea mali ho bakuli ba nang le lefu la tsoekere la mofuta oa 2. Ho boetse ho fumanoe ho khothalletsa ho theola boima ba 'mele, e leng phaello e eketsehileng ho batho ba bangata ba nang le lefu la tsoekere la mofuta oa 2 ba nang le bothata ba ho boloka boima ba 'mele bo botle. O mong oa melemo ea tezeparatide ke mokhoa oa eona oa ho noa hang ka beke, o ka eketsang boiketlo le ho latela mokhoa oa kalafo. Sena se ka ba molemo haholo ho batho ba nang le bothata ba ho latela kemiso ea letsatsi le letsatsi ea meriana kapa ba khethang moralo o hlophisitsoeng oa kalafo. Ho lokela ho hlokomeloa hore tilsparatide e ntse e le sethaleng sa lipatlisiso 'me ha e e-s'o amoheloe hore e sebelisoe ke mekhatlo ea tsamaiso. Ho hlokahala lipatlisiso tse ling ho fumana polokeho le katleho ea nako e telele le ho tseba litlamorao tse ka bang teng. Ka kakaretso, tilsiparatide ke setlhare se secha se ntseng se etsoa lipatlisiso bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2. Ketso ea eona e habeli ho li-receptor tsa GIP le GLP-1 e na le monyetla oa ho ntlafatsa taolo ea glycemic le tahlehelo ea boima ba 'mele. Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng pele tilsiparatide e ka khothaletsoa e le khetho ea kalafo bakeng sa batho ba nang le lefu la tsoekere la mofuta oa 2. |
| Sephutheloana: | aluminium foil bag kapa aluminium TIN kapa ho latela litlhoko tsa moreki |
| 1 | Morekisi oa litsebi oa li-API tsa peptide ho tsoa Chaena. |
| 2 | Mehala ea tlhahiso ea 16 e nang le matla a lekaneng a tlhahiso a maholo ka theko ea tlhōlisano |
| 3 | DMF e fumaneha ka litokomane tse tšepahalang haholo. |
A: E, re ka paka e le tlhoko ea hau.
A: LC sight le TT esale pele nako ea tefo e khethiloeng.
K: E, ka kopo fana ka litlhaloso tsa hau tsa boleng, re tla hlahloba R&D ea rona mme re leke ho tsamaisana le litlhaloso tsa hau tsa boleng.
Ngola molaetsa wa hao mona mme o re romele wona
